Principles of Magnetic Resonance, Spring 2020
General Information:
Course: Arizona State University (ASU): ASU-Tempe Campus & ASU-Online
Biochemistry (BCH) & Chemistry (CHM) 494 & 598 (Special Topics)
Wednesday 3:05-5:50 PM, 1/13/20 – 5/1/20 (Spring Semester, 2020)
Physical Sciences Building (PS), Tempe PSH 132.
Interdisciplinary Science and Technology Bldg. 1 (ISTB1), Rm L2-63
3 credit hours, ASU Schedule Line # 32819, 32802, 32818 & 32790.
Instructor: Prof. Jeff Yarger, ISTB1 412, jeff.yarger@asu.edu (yarger@biopchem.education)
Office hours: 5:00-7:00 PM, Wednesday, in ISTB1 L2-63, or by appointment
NMR: The primary NMR’s used for this class are located in ISTB1 L2-63. Instruments will be made available online (remote access) on Wed. from 4:00 PM – 5:50 PM.
Web Site: (LMS) https://canvas.asu.edu (Yarger) https://biopchem.education
Course Resources & Materials
Primary Website: ASU uses Canvas as its online learning platform. All information regarding this course will be posted to the ASU Canvas website. ASU Online Course info can be found generally at my.asu.edu and the direct link to Canvas at ASU can be found at https://canvas.asu.edu
Textbook: No required materials or textbooks. However, I would suggest the following as excellent books and reference material for magnetic resonance:
(1) Malcom Levitt, “Spin Dynamics: Basics of Nuclear Magnetic Resonance”, 2nd Ed.
(2) James Keeler, “Understanding NMR Spectroscopy”, 2nd Ed.
(3) David Goldenberg, “Principles of NMR Spectroscopy”
(4) John Cavanagh, “Protein NMR Spectroscopy: Principles and Practice.”, 2nd Ed.
(5) Stefan Berger, “300 and More NMR Experiments: A Practical Course.”
I would also recommend two online books for reference (and Wikipedia):
http://www.cis.rit.edu/htbooks/nmr/
http://www.cis.rit.edu/htbooks/mri/
Course Lectures: Lectures are designed to outline, discuss, and demonstrate principles of magnetic resonance. Lecture notes will be posted on the class website (biopchem.education). The course is taught online and/or in PSH-132 for discussion. The NMR instruments are located at ASU-Tempe, ISTB1 L2-63.
Magnetic Resonance Projects
This course is designed to provide an overview of principles and methods in magnetic resonance including Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). Class projects are designed to allow students to obtain experience in one or more specific area of magnetic resonance that best suits their research interests. All projects must be submitted online and will include a screencast (or in-class presentation that will be recorded). The original typeset files, PDF version and all associated data files should be submitted as a single zip file. The instructor must approve project topics and outlines and the due dates are listed below:
Topic & Outline Approval Project Due Date
Project 1: Wed., Feb. 19th Wed., March 4th
Project 2: Wed., April 15th Wed., April 29th
Magnetic Resonance has a plethora of different types of experiments, probe designs, pulse sequences, data collection techniques, data simulation and modeling methods. This large variety of “methods” in magnetic resonance and can make it overwhelming for new scientists trying to learn how-to setup and perform a specific experiment. Class projects will all have a common section scheme and taken together will provide the nucleus for a series of “How-To” guides in principles of magnetic resonance. Each project will have the goal of providing a self-contained guide on one specific “Principle” (or “Method”) in magnetic resonance. Specifically, the oral or written (screencast or website/blog for online students) report should enable the reader to understand the general technique (method or principles) and provide a “learn by doing” guideline.
NMR Molecular Structure Elucidation
A primary pillar of NMR is its ability to determine the molecular structure of organic molecules and compounds. It is important that this class cover the basic techniques that allow NMR to be used from structure determination. Students will be given two unknown compounds during the semester (or online students will be given remote access to the unknown compound dissolved in a deuterated solvent in a standard 3 or 5 mm NMR tube). The students task will be determining the molecular structure of the unknown compounds. These structure elucidation projects are designed to allow students to obtain practical NMR experience (data analysis and interpretation experience). Below is the tentative schedule for these exercises:
Provided to Student Screencast Due Date
Compound 1: Wed., Jan. 29th Wed., Feb. 12th
Compound 2: Wed., March 18th Wed., April 1st
Students will summarize all NMR experiments used to determine the structure of their unknown compound and will be graded on their ability to determine the correct molecular structure of the unknown compound. Proper explanation of how the NMR data was used to determine the molecular structure is also a key evaluation criteria. The preferred format for evaluation is a ~5-10 min screencast (or in-class presentation for on-ground students) or ~2-3 page summary report (in PDF format) with all ancillary material provided as supplementary material.
Course Evaluation (Grades)
Your grade for the class will be based on student and instructor evaluation of the magnetic resonance projects and molecular structure elucidation. Projects will be given an A-F grade. Projects should be written in a publication style similar to the American Journal of Physics or the Journal of Chemical Education. An “A” represents a project that can be used without any corrections or revisions. A “B” will be a submitted project that requires small or minor editing. A “C” will be a project that requires major editing before it would be acceptable for publication on the Magnetic Resonance Research Center (MRRC) website. A “D” or “F” would represent incomplete or extremely poor project reports. Peer review/assessment will be incorporated as a primary grading and feedback mechanism.
Syllabus Disclaimer
The syllabus is a statement of intent and serves as an implicit agreement between the instructor and the student. Every effort will be made to avoid changing the course schedule but the possibility exists that unforeseen events will make syllabus changes necessary. Please remember to check your ASU email and the course site often.
Accessibility Statement
In compliance with the Rehabilitation Act of 1973, Section 504, and the Americans with Disabilities Act as amended (ADAAA) of 2008, professional disability specialists and support staff at the Disability Resource Center (DRC) facilitate a comprehensive range of academic support services and accommodations for qualified students with disabilities.
Qualified students with disabilities may be eligible to receive academic support services and accommodations. Eligibility is based on qualifying disability documentation and assessment of individual need. Students who believe they have a current and essential need for disability accommodations are responsible for requesting accommodations and providing qualifying documentation to the DRC. Every effort is made to provide reasonable accommodations for qualified students with disabilities.
Qualified students who wish to request an accommodation for a disability should contact the DRC by going to https://eoss.asu.edu/drc, calling (480) 965-1234 or emailing DRC@asu.edu. To speak with a specific office, please use the following information:
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ASU Online and Downtown Phoenix Campus University Center Building, Suite 160 602-496-4321 (Voice) |
Polytechnic Campus 480-727-1165 (Voice) |
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West Campus University Center Building (UCB), Room 130 602-543-8145 (Voice) |
Tempe Campus 480-965-1234 (Voice) |
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BioPchem 